Opportunity Information: Apply for PAS 18 915
The HIV/AIDS High Priority Drug Abuse Research (R01 Clinical Trial Optional) opportunity (PAS-18-915) is a discretionary NIH grant program from the U.S. Department of Health and Human Services designed to spur new, high-impact research at the intersection of drug misuse and HIV/AIDS. It is explicitly aligned with NIH-wide HIV/AIDS research priorities laid out for the following three to five years in NOT-OD-15-137, and it is intended to push the field toward studies that address the most urgent and consequential questions linking substance use and HIV prevention, treatment, and overall health outcomes. In practical terms, the FOA is meant to encourage investigators to propose rigorous projects that generate actionable knowledge about how drug misuse affects HIV transmission risk, access to and retention in care, treatment adherence, viral suppression, comorbidities, and related public health outcomes.
This FOA uses the R01 mechanism, meaning it supports substantial, typically multi-year research projects that are hypothesis-driven and methodologically strong. The “Clinical Trial Optional” designation signals flexibility: applicants may propose studies that do not include a clinical trial, but they can also propose clinical trials when they are scientifically justified and fit the research aims. That makes the announcement broad enough to accommodate basic, behavioral, clinical, services, and implementation-focused work, as long as the proposed research is clearly connected to the combined challenges of drug misuse and HIV/AIDS and responds to high-priority needs.
Eligibility is wide and includes many types of domestic organizations and governments. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (including those outside higher education); for-profit organizations other than small businesses; small businesses; and other organizations as described in NIH eligibility language. This broad eligibility reflects NIH’s interest in drawing in strong proposals from academic research centers, healthcare systems, community-based organizations, tribal entities, governmental public health agencies, and private-sector partners with the expertise and infrastructure to conduct high-quality HIV and substance use research.
From an administrative standpoint, the listing identifies the program as a grant in the Education and Health activity category and associates it with CFDA number 93.279. The opportunity was created on September 10, 2018, with an original closing date of September 7, 2021, and it projected approximately four awards. The award ceiling is listed as 0, which typically indicates no single fixed cap is provided in the public summary and that budgets are expected to be appropriate to the project scope and consistent with NIH policy and the specific institute’s budget considerations.
Overall, the core purpose of PAS-18-915 is to accelerate progress on HIV/AIDS by targeting drug misuse as a key driver of risk and poor outcomes, and by encouraging well-designed research that can inform prevention strategies, improve treatment and care engagement, and strengthen real-world interventions and service delivery approaches for populations affected by both substance use and HIV.Apply for PAS 18 915
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HIV/AIDS High Priority Drug Abuse Research (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on Sep 10, 2018.
- Applicants must submit their applications by Sep 07, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Administrative Supplements to Cancer Center Support Grants to Strengthen the Research, Training, and Outreach Capacity of the Geographic Management of Cancer Health Disparities Program (Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 934 Funding Number: PA 18 934 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Optional) Apply for RFA DA 19 008 Funding Number: RFA DA 19 008 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) Apply for PAR 19 032 Funding Number: PAR 19 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators of the National Outreach Network (Admin Suppl Clinical Trial Not Allowed) Apply for PA 19 035 Funding Number: PA 19 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Immuno-Oncology Translation Network (IOTN): Immuno-engineering to Improve Immunotherapy (i3) Centers (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 013 Funding Number: RFA CA 19 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $900,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 19 024 Funding Number: RFA DA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Methodology and Advanced Analytics Resource Center (U2C Clinical Trial Not Allowed) Apply for RFA DA 19 023 Funding Number: RFA DA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed) Apply for RFA CA 19 029 Funding Number: RFA CA 19 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required) Apply for RFA CA 19 030 Funding Number: RFA CA 19 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 022 Funding Number: RFA CA 19 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 021 Funding Number: RFA CA 19 021 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 020 Funding Number: RFA CA 19 020 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 019 Funding Number: RFA CA 19 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 19 027 Funding Number: RFA CA 19 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 19 026 Funding Number: RFA CA 19 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 19 023 Funding Number: RFA CA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 19 024 Funding Number: RFA CA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Distance Learning and Telemedicine Grants. Apply for RUS 19 02 DLT Funding Number: RUS 19 02 DLT Agency: Department of Agriculture, Utilities Programs Category: Education, Health Funding Amount: $500,000 |
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