Opportunity Information: Apply for RFA CE 19 002

The Centers for Disease Control and Prevention (CDC), through the National Center for Injury Prevention and Control (NCIPC), offered this grant opportunity to support investigator-initiated research focused on preventing both fatal and nonfatal opioid overdoses. The main goal is not basic science or early-stage intervention development, but practical, real-world evaluation of strategies that states, communities, and larger service systems can implement at scale. The program is designed to produce results that state and local health departments can use quickly, with a clear emphasis on shortening the usual gap between identifying what works and putting it into widespread practice.

Projects funded under this opportunity are expected to study the implementation and impact of either new or existing approaches operating in real settings. The CDC highlights five major strategy areas that applicants can target. First, research can examine ways to increase effective use of Prescription Drug Monitoring Programs (PDMPs), such as methods that improve clinician engagement, workflow integration, data access, and routine use in prescribing decisions. Second, the funding supports studies that help providers and health systems improve prescribing practices, pain management, and overdose response, which can include evaluation of clinical policies, decision-support tools, training models, quality improvement efforts, and health system protocols that reduce risk while maintaining appropriate care. Third, the NOFO encourages research that strengthens public health systems that connect people to care for opioid use disorder and overdose, including mechanisms for referral, follow-up, navigation, and linkage to treatment and recovery supports. Fourth, applicants may evaluate strategies that bring public health approaches into public safety and law enforcement responses, reflecting interest in coordinated, cross-sector models that reduce harm and improve outcomes. Fifth, the CDC is interested in interventions that empower individuals to make safer choices related to opioid use, which can include education, risk communication, naloxone-related strategies, and other person-centered approaches aimed at reducing overdose risk.

A central theme across the NOFO is implementation at the state, community, and systems level. The research is meant to improve how interventions are carried out in practice, not just whether an intervention can work under ideal conditions. That means strong proposals would typically pay attention to factors like feasibility, adoption, fidelity, reach into affected populations, coordination across agencies, barriers and facilitators to implementation, and measurable effects on overdose outcomes and related indicators. The CDC also signals a preference for studies that yield findings that can be translated into action immediately, so projects should be designed to generate practical guidance that health departments and partners can apply without waiting years for additional development.

Administratively, this is a discretionary grant opportunity from the Department of Health and Human Services (HHS), CDC. The funding opportunity number is RFA CE 19 002, listed under CFDA 93.136, with a health-focused activity category. The opportunity anticipated making about 13 awards, with an award ceiling of $769,230. The opportunity was posted on January 25, 2019, with an original application deadline of April 8, 2019, and applications were required to be submitted electronically by 5:00 p.m. Eastern Time on the due date.

Eligibility was broad and included multiple types of applicants that could realistically conduct or partner on applied public health research. Eligible entities included state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. This wide eligibility reflects the cross-sector nature of overdose prevention work and the expectation that effective studies may require collaborations among public health agencies, healthcare systems, academic partners, community organizations, and public safety entities.

Overall, the opportunity is best understood as a push for actionable, practice-ready evidence: rigorous evaluation of strategies that can be implemented now, tested in the environments where overdose prevention actually happens, and translated quickly into improved state and local responses to the opioid overdose crisis.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Research Grants to Identify Effective Strategies for Opioid Overdose Prevention" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
  • This funding opportunity was created on Jan 25, 2019.
  • Applicants must submit their applications by Apr 08, 2019 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $769,230.00 in funding.
  • The number of recipients for this funding is limited to 13 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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