Opportunity Information: Apply for ARPA H SN 23 01
The NITRO OA Model Symposium (Funding Opportunity Number ARPA-H SN 23 01) is a government-sponsored research-focused convening organized by the Advanced Research Projects Agency for Health (ARPA-H), specifically through its Health Science Futures Office. The purpose of the symposium is to bring together relevant experts and stakeholders to identify what the field should consider the most suitable osteoarthritis (OA) models for advancing therapy development, with an emphasis on two areas: large animal models that best mimic human osteoarthritis and in vitro (lab-based) model systems that can reliably reproduce key disease features in controlled settings. In practical terms, ARPA-H is trying to push the community toward better-aligned, higher-confidence model choices so that OA research and preclinical testing can become more predictive, comparable across teams, and ultimately more useful for translating concepts into treatments.
This symposium is tied to ARPA-Hs broader NITRO program goals. NITRO is centered on the problem that osteoarthritis remains difficult to treat in a way that restores joint structure and function, and current options often focus on managing symptoms or replacing the joint rather than rebuilding it. The program vision described here is to develop new approaches that help the human body repair its own joints. The symposium is intended to support that vision by zeroing in on foundational research infrastructure questions: which animal models most faithfully reflect human joint degeneration, pain, inflammation, biomechanics, and progression over time, and which in vitro systems can capture the biology needed for rapid iteration, screening, and mechanistic insight.
Although it is related to the NITRO Broad Agency Announcement (BAA), ARPA-H explicitly notes that the symposium is independent of the BAA. That distinction matters for organizations tracking funding pathways: the symposium is its own Special Notice and engagement opportunity, while the BAA is the formal mechanism through which ARPA-H may solicit and fund project proposals under the NITRO program. The listing points interested parties to the Special Notice attachment for full participation details and references the NITRO BAA on SAM.gov and Grants.gov for those exploring the main program solicitation and potential future funding submissions.
Administratively, the opportunity is categorized as "Other" rather than a standard grant program, with an activity category of Science and Technology and other Research and Development, and it lists CFDA number 93.384. Eligibility is described as unrestricted, which generally signals that participation is open to a broad range of entities rather than being limited to a specific applicant type, though any concrete requirements would be spelled out in the Special Notice. The original closing date shown is September 8, 2023, and the posting date is July 26, 2023. The notice does not specify an award ceiling or expected number of awards in the provided text, consistent with the idea that this is primarily a symposium-focused Special Notice rather than a conventional grant award announcement.Apply for ARPA H SN 23 01
- The Advanced Research Projects Agency for Health in the science and technology and other research and development sector is offering a public funding opportunity titled "NITRO OA Model Symposium" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.384.
- This funding opportunity was created on 2023-07-26.
- Applicants must submit their applications by 2023-09-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Unrestricted.
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FAQs: NITRO OA Model Symposium (ARPA-H SN 23 01)
What is the NITRO OA Model Symposium (Funding Opportunity Number ARPA-H SN 23 01)?
The NITRO OA Model Symposium (ARPA-H SN 23 01) is a government-sponsored, research-focused convening (a symposium) organized by the Advanced Research Projects Agency for Health (ARPA-H) through its Health Science Futures Office.
Which agency is sponsoring and organizing this opportunity?
This opportunity is organized by ARPA-H (Advanced Research Projects Agency for Health), specifically through ARPA-H's Health Science Futures Office.
What is the main purpose of the symposium?
The purpose is to bring together relevant experts and stakeholders to identify what the field should consider the most suitable osteoarthritis (OA) models for advancing therapy development. The intent is to help align the community around better, higher-confidence model choices so OA research and preclinical testing can be more predictive and comparable across teams, and ultimately more useful for translating concepts into treatments.
What disease area is the symposium focused on?
The symposium focuses on osteoarthritis (OA), with attention to how models can support therapy development and translational progress.
What specific model types are emphasized?
ARPA-H highlights two emphasis areas: (1) large animal models that best mimic human osteoarthritis, and (2) in vitro (lab-based) model systems that can reliably reproduce key disease features in controlled settings.
Why is ARPA-H emphasizing large animal models?
Based on the notice description, large animal models are emphasized because ARPA-H wants the field to identify models that most faithfully reflect key aspects of human OA, such as joint degeneration, pain, inflammation, biomechanics, and progression over time.
Why is ARPA-H emphasizing in vitro model systems?
ARPA-H is emphasizing in vitro systems because they can capture disease biology in controlled settings and support rapid iteration, screening, and mechanistic insight, which can speed up learning and improve confidence in preclinical findings.
What problems in osteoarthritis does the broader NITRO program aim to address?
The description states that osteoarthritis remains difficult to treat in ways that restore joint structure and function. Current options often focus on managing symptoms or replacing the joint rather than rebuilding it. NITRO's vision, as described here, is to develop new approaches that help the human body repair its own joints.
How does this symposium relate to the broader NITRO program goals?
The symposium supports NITRO's vision by focusing on foundational research infrastructure questions: which animal models best reflect human OA and which in vitro systems can capture the biology needed for faster testing, comparison, and insight that may help translate ideas into treatments.
Is this symposium the same thing as the NITRO Broad Agency Announcement (BAA)?
No. ARPA-H explicitly notes that the symposium is independent of the NITRO BAA. The symposium is described as its own Special Notice and engagement opportunity, while the BAA is the formal mechanism through which ARPA-H may solicit and fund project proposals under the NITRO program.
If an organization wants funding for a project, should it rely on this symposium notice?
The text provided characterizes this listing as a symposium-focused Special Notice and notes that it does not specify an award ceiling or expected number of awards. For organizations exploring the main program solicitation and potential future funding submissions, the notice points to the NITRO BAA on SAM.gov and Grants.gov.
Where are the full participation details for the symposium expected to be found?
The listing directs interested parties to the Special Notice attachment for full participation details.
What is the funding opportunity number associated with this symposium?
The funding opportunity number is ARPA-H SN 23 01.
How is this opportunity categorized (grant vs. other)?
Administratively, the opportunity is categorized as "Other" rather than a standard grant program.
What is the activity category listed for this opportunity?
The activity category is listed as Science and Technology and other Research and Development.
What CFDA number is associated with this opportunity?
The notice lists CFDA number 93.384.
Who is eligible to participate?
Eligibility is described as unrestricted, which generally indicates participation is open to a broad range of entities rather than limited to a specific applicant type. Any concrete requirements would be spelled out in the Special Notice attachment.
Does the notice state an award ceiling or the expected number of awards?
No. The provided text states that the notice does not specify an award ceiling or expected number of awards, which is consistent with it being primarily a symposium-focused Special Notice rather than a conventional grant award announcement.
What are the key scientific considerations the symposium wants models to capture?
The description highlights model fidelity to human OA features including joint degeneration, pain, inflammation, biomechanics, and progression over time. It also highlights the need for in vitro systems that can reproduce key disease features reliably in controlled settings.
What is the practical outcome ARPA-H is trying to drive through this symposium?
In practical terms, ARPA-H aims to push the community toward better-aligned, higher-confidence OA model choices so that research and preclinical testing are more predictive, more comparable across teams, and more useful for translation into treatments.
What are the posting date and the closing date listed in the notice?
The posting date is July 26, 2023, and the original closing date shown is September 8, 2023.
Is this opportunity described as a research-focused convening rather than a project solicitation?
Yes. The description frames the opportunity as a research-focused convening (symposium) intended to bring together experts and stakeholders to identify suitable OA models, rather than as a conventional grant program announcing awards.
Where does the notice direct people who want to explore the NITRO program solicitation?
The notice references the NITRO BAA on SAM.gov and Grants.gov for those exploring the main program solicitation and potential future funding submissions.
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