NHLBI Program Project Applications (P01 Clinical Trials Optional) | PAR 24 065

Opportunity Information: Apply for PAR 24 065

The NHLBI Program Project Applications funding opportunity (PAR 24 065) is a National Institutes of Health discretionary grant mechanism that uses the P01 Program Project Grant activity code, with clinical trials listed as optional. It is designed to support coordinated, collaborative research that aligns with NHLBI's mission across heart, lung, blood, and lymphatic vessel biology and disease, including areas such as transfusion medicine, blood resources, and sleep disorders. The announcement also makes clear that NHLBI is interested in program project approaches that incorporate implementation science, health disparities research, and translational efforts when these are relevant to the Institute's core mandate.

A defining feature of this opportunity is the expectation of a true program, not a bundle of loosely connected studies. Applications must include at least three interrelated research projects that work together to address a complex biomedical theme or a central research question. Each project should contribute a distinct scientific aim, but the overall program needs to show clear thematic integration and meaningful interaction among the projects, with a strong rationale for why the work will move faster or farther as a coordinated unit than it would as separate, independent grants. To strengthen efficiency and shared progress, applicants may also propose core units (for example, shared resources, specialized services, data coordination, or shared equipment), but these cores must be well justified in terms of economy of effort, space, and equipment and should directly enable the projects to function as an integrated program.

NHLBI frames the P01 mechanism as a way to accelerate discovery by encouraging team science and collaborative structures that create synergy, cross-fertilization of ideas, and shared infrastructure. The Institute explicitly signals interest in applications that open up new scientific directions and notes that the P01 can be a pathway to attract investigators who have not traditionally received NHLBI support. The program project environment is also positioned as a leadership development setting, and applicants have the option to include a project led by an Early Stage Investigator (ESI), which can help cultivate emerging scientific leaders while still contributing substantively to the program's central theme.

Eligibility is broad and includes many types of U.S.-based entities, such as state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other eligible organizations. The announcement also highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign organizations (non-U.S. entities) are not eligible to apply as the applicant organization; however, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement.

Key administrative details included in the source information are the funding instrument type (grant), the health activity category, and associated CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840). The opportunity was created on 2023-11-20, and the listed original closing date is 2026-09-25. The provided source text does not specify an award ceiling or expected number of awards, so applicants would typically look to the full FOA and NHLBI guidance for budgeting expectations, scope, and review considerations.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Program Project Applications (P01 Clinical Trials Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
• This funding opportunity was created on 2023-11-20.
• Applicants must submit their applications by 2026-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 24 065

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