Opportunity Information: Apply for PAR 19 161
The NIDCR Mentored Career Development Award to Promote Diversity in the Dental, Oral and Craniofacial Workforce (K01 Independent Basic Experimental Studies with Humans Required), PAR-19-161, is a National Institutes of Health career development grant designed to help build a more diverse pool of independently funded researchers in dental, oral, and craniofacial (DOCR) science. The central aim is to support eligible postdoctoral fellows and early career faculty from diverse backgrounds, including individuals from groups that are underrepresented in the biomedical and behavioral sciences, by giving them a structured, mentored pathway toward research independence. The award is meant to provide a sustained period of protected time so the recipient can focus intensely on research and career development rather than being pulled primarily into other institutional responsibilities.
A key feature of this particular K01 announcement is that it is specifically intended for basic science experimental studies that involve humans and that meet the NIH definition of a clinical trial, while still being considered basic research. In practice, that means the proposed project should prospectively assign human participants to one or more conditions, typically by experimentally manipulating an independent variable, and then measure biomedical or behavioral outcomes in humans. The purpose must be to understand fundamental mechanisms or phenomena rather than to test or refine a product, intervention, or process for a specific practical application. This distinction matters because NIDCR and NIH route different kinds of human-subjects research to different funding announcements: if the work is oriented toward specific applications (for example, developing or optimizing a treatment approach or product), applicants are directed to use the companion Clinical Trial Required FOA (PAR-18-359) instead.
This FOA also draws a line between applicants who will lead an independent clinical trial (even if it is basic experimental work) and those who are not planning to run their own trial. If an applicant is not proposing an independent clinical trial, or if the goal is to gain experience by working on a clinical trial led by another investigator, they are instructed to apply to a companion FOA (listed in the text as PAR-19-NNN). In other words, PAR-19-161 is aimed at candidates who will be responsible for a prospective, basic experimental human study that qualifies as a clinical trial, conducted within a mentored career development framework.
In terms of what the award supports, the announcement emphasizes both salary and research support over a sustained period, with the explicit intent of enabling protected time for career development. The structure is built around close guidance from an experienced mentor, reflecting the K01 mechanism goal of transitioning promising early-stage investigators into independent, externally funded researchers. While the summary does not list detailed budget levels, award ceilings, or the number of expected awards, it clearly frames the program as an investment in the candidate's development through mentored research, training, and progression toward independence in the DOCR research workforce.
Eligibility is broad on the institutional side, spanning many common NIH applicant categories such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various levels of government (state, county, city or township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. The FOA also highlights additional eligible applicant types that align with the diversity mission, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain tribal governments and tribal organizations (including some that are not federally recognized, as specified).
At the same time, the announcement is explicit about restrictions related to non-U.S. applicants and components. Non-domestic (non-U.S.) entities (foreign organizations/institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning a U.S.-based applicant organization may, under NIH rules, include certain justified foreign elements within an otherwise eligible application.
Administratively, this is an NIH discretionary grant opportunity within the health funding activity category, associated with CFDA number 93.121, and it was created on 2019-01-08. The original closing date listed in the provided data is 2022-01-07. Overall, the program is best understood as a mentored, early-career research award from NIDCR that combines career development structure with funding support, targeted specifically to diversify the DOCR research pipeline and to support basic experimental studies in humans that qualify as clinical trials but are driven by fundamental scientific questions rather than immediate clinical or product-focused applications.Apply for PAR 19 161
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Mentored Career Development Award to Promote Diversity in the Dental, Oral and Craniofacial Workforce (K01 Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on 2019-01-08.
- Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIDCR Mentored Career Development Award to Promote Diversity in the Dental, Oral and Craniofacial Workforce (K01) - PAR-19-161
What is PAR-19-161?
PAR-19-161 is an NIDCR (National Institute of Dental and Craniofacial Research) Mentored Career Development Award (K01) intended to help build a more diverse pool of independently funded researchers in dental, oral, and craniofacial (DOCR) science. It supports a structured, mentored pathway toward research independence for eligible postdoctoral fellows and early career faculty from diverse backgrounds.
What is the main goal of this K01 program?
The central aim is to promote diversity in the DOCR research workforce by supporting promising early-stage researchers and providing them with sustained protected time, mentorship, and resources to develop into independent, externally funded investigators.
Who is this award designed to support (career stage)?
It is designed for eligible postdoctoral fellows and early career faculty who are on a mentored trajectory toward research independence.
Who is this award designed to support (diversity focus)?
The program is intended to support individuals from diverse backgrounds, including individuals from groups that are underrepresented in the biomedical and behavioral sciences, consistent with the FOA's diversity mission.
What kind of research does PAR-19-161 specifically require?
This FOA is specifically intended for basic science experimental studies that involve humans and that meet the NIH definition of a clinical trial, while still being considered basic research.
Does the proposed project have to be a clinical trial?
Yes. A defining feature of this announcement is that the proposed basic experimental human study must meet the NIH definition of a clinical trial.
How does NIH define the type of human study expected under this FOA?
In practice, the project should prospectively assign human participants to one or more conditions (often by experimentally manipulating an independent variable) and measure biomedical or behavioral outcomes in humans. The purpose must be to understand fundamental mechanisms or phenomena rather than to test or refine a product, intervention, or process for a specific practical application.
What makes a study "basic experimental" even if it is a clinical trial?
Under this FOA, the study can still be considered basic research if it is designed to understand fundamental mechanisms or phenomena. The key distinction described is that the work should not be oriented toward a specific practical application such as developing, optimizing, or refining a treatment approach or product.
What if my human study is focused on developing or optimizing a treatment or product?
If the work is oriented toward specific applications (for example, developing or optimizing a treatment approach or product), applicants are directed to use the companion Clinical Trial Required FOA, PAR-18-359, rather than PAR-19-161.
Is PAR-19-161 appropriate if I will not lead my own clinical trial?
No. This FOA draws a line between applicants who will lead an independent clinical trial and those who will not. If you are not proposing an independent clinical trial, or if your goal is to gain experience by working on a clinical trial led by another investigator, you are instructed to apply to a companion FOA referenced as PAR-19-NNN.
What does "independent clinical trial" mean in the context provided?
Based on the description provided, it means the candidate will be responsible for a prospective basic experimental human study that qualifies as a clinical trial, conducted within a mentored career development framework (as opposed to only participating in a trial led by another investigator).
What does the award support?
The announcement emphasizes support for both salary and research over a sustained period, with the explicit intent of enabling protected time for career development and mentored research.
Why is "protected time" emphasized?
The program is designed to provide a sustained period of protected time so the recipient can focus intensely on research and career development rather than being pulled primarily into other institutional responsibilities.
How important is mentorship under this award?
Mentorship is a core feature. The structure is built around close guidance from an experienced mentor, reflecting the K01 mechanism goal of transitioning early-stage investigators into independent, externally funded researchers.
Does the provided summary include budget limits or the number of awards?
No. The summary provided does not list detailed budget levels, award ceilings, or the number of expected awards. It does, however, frame the program as an investment in the candidate's development through mentored research, training, and progression toward independence.
What scientific area does NIDCR expect this K01 to address?
The focus is on dental, oral, and craniofacial (DOCR) science, with projects aligned to basic experimental studies in humans that qualify as clinical trials and are intended to illuminate fundamental mechanisms or phenomena.
What types of applicant organizations are eligible?
Eligibility is broad on the institutional side and includes public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and various levels of government (state, county, city or township, and special districts), as well as independent school districts and public housing authorities/Indian housing authorities.
Are minority-serving and community-based institutions included in eligible applicants?
Yes. The FOA highlights additional eligible applicant types aligned with the diversity mission, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain tribal governments and tribal organizations (including some that are not federally recognized, as specified).
Can foreign (non-U.S.) organizations apply?
No. Non-domestic (non-U.S.) entities (foreign organizations/institutions) are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
Non-domestic components of U.S. organizations are not eligible. However, foreign components (as defined in the NIH Grants Policy Statement) are allowed, meaning a U.S.-based applicant organization may include certain justified foreign elements within an otherwise eligible application under NIH rules.
What agency and grant type is this opportunity associated with?
This is an NIH discretionary grant opportunity within the health funding activity category, associated with CFDA number 93.121.
When was this funding opportunity created, and what closing date is listed?
The opportunity was created on 2019-01-08, and the original closing date listed in the provided information is 2022-01-07.
What is the simplest way to decide whether PAR-19-161 is the right FOA?
Based on the information provided: PAR-19-161 fits if you are an eligible early-career candidate seeking mentored career development in DOCR research and you will be responsible for a prospective basic experimental human study that meets the NIH definition of a clinical trial and is aimed at fundamental mechanisms (not a specific practical application). If your study is application-focused, PAR-18-359 is indicated; if you will not lead an independent clinical trial, the companion FOA referenced as PAR-19-NNN is indicated.
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| Funding Opportunity |
|---|
| NIDCR Mentored Career Development Award to Promote Diversity in the Dental, Oral and Craniofacial Workforce (K01 Independent Clinical Trial Not Allowed) Apply for PAR 19 160 Funding Number: PAR 19 160 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed) Apply for PAR 19 145 Funding Number: PAR 19 145 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional) Apply for PAR 19 155 Funding Number: PAR 19 155 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Independent Basic Experimental Studies with Humans Required) Apply for PAR 19 151 Funding Number: PAR 19 151 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Bioengineering Research Partnerships (U01 Clinical Trial Required) Apply for PAR 19 157 Funding Number: PAR 19 157 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The Human Biomolecular Atlas Program (HuBMAP): Rapid Implementation of Technologies that Will Accelerate Development of a Framework for Mapping the Human Body at High Resolution (UH3 Clinical Trial Not Allowed) Apply for RFA RM 19 002 Funding Number: RFA RM 19 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional) Apply for RFA MD 19 001 Funding Number: RFA MD 19 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Center for Natural Product Technology, Methodology, and Productivity Optimization (NP-TEMPO) (U41 Clinical Trial Not Allowed) Apply for RFA AT 19 003 Funding Number: RFA AT 19 003 Agency: National Institutes of Health Category: Health Funding Amount: $700,000 |
| Botanical Dietary Supplements Research Centers (U19 Clinical Trial Optional) Apply for RFA OD 19 001 Funding Number: RFA OD 19 001 Agency: National Institutes of Health Category: Health Funding Amount: $1,200,000 |
| Natural Products NMR Open Data Exchange (NP-NODE) (U24 Clinical Trial Not Allowed) Apply for RFA AT 19 002 Funding Number: RFA AT 19 002 Agency: National Institutes of Health Category: Health Funding Amount: $900,000 |
| Implementation of shared decision making for HLBS diseases and conditions (R01 Clinical Trial Optional) Apply for PA 19 166 Funding Number: PA 19 166 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Development and Validation of Advanced Mammalian Models for Alzheimers Disease-Related Dementias (ADRD) (R61/R33 Clinical Trial Not Allowed) Apply for PAR 19 167 Funding Number: PAR 19 167 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mechanistic studies on chronic alcohol use and sleep homeostasis (R01 Clinical Trial Optional) Apply for RFA AA 19 006 Funding Number: RFA AA 19 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Progression Markers for Cognitive Impairment in Parkinson's Disease Dementia (R01 Clinical Trial Not Allowed) Apply for PAR 19 170 Funding Number: PAR 19 170 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional) Apply for RFA HL 20 011 Funding Number: RFA HL 20 011 Agency: National Institutes of Health Category: Health Funding Amount: $600,000 |
| NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional) Apply for RFA HL 20 012 Funding Number: RFA HL 20 012 Agency: National Institutes of Health Category: Health Funding Amount: $600,000 |
| Comparative Effectiveness Research in Clinical Neurosciences (UG3/UH3 Clinical Trial Not Allowed) Apply for PAR 19 171 Funding Number: PAR 19 171 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Achieving Tissue Robustness Through Harnessing Immune System Plasticity (R21 Clinical Trial Not Allowed) Apply for PAR 19 173 Funding Number: PAR 19 173 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Achieving Tissue Robustness Through Harnessing Immune System Plasticity (R01 Clinical Trial Not Allowed) Apply for PAR 19 172 Funding Number: PAR 19 172 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Shared Instrumentation for Animal Research (SIFAR) Grant Program (S10 Clinical Trial Not Allowed) Apply for PAR 19 178 Funding Number: PAR 19 178 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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