NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required) | PAR 19 302

Opportunity Information: Apply for PAR 19 302

The NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required), funding opportunity number PAR-19-302, is a discretionary grant program from the National Institutes of Health (NIH) through the National Institute on Aging (NIA). It supports the implementation of investigator-initiated, multi-site interventional clinical trials across any trial phase, meaning applicants can propose everything from early-stage clinical testing through later-phase effectiveness work as long as the project fits NIA's scientific priorities. The central emphasis is on trials that are hypothesis-driven, with clearly articulated scientific questions and outcomes, and that are milestone-defined, meaning the study is expected to include concrete, measurable progress points that guide trial execution and allow for accountability during the life of the award. In practical terms, this FOA is focused on actually running the clinical trial (implementation) rather than only planning, preliminary feasibility exploration, or purely observational work.

Projects submitted under this announcement are expected to align with NIA's research mission, which broadly covers aging-related science and health, including conditions and challenges that disproportionately affect older adults and aging populations. Because the FOA is explicitly for multi-site interventional trials, applications generally need to demonstrate the ability to coordinate research activities across multiple locations, maintain consistent protocols and data quality, and manage operational issues like recruitment, retention, intervention delivery, and standardized outcome assessment across sites. The "clinical trial required" designation signals that the proposed work must meet NIH's definition of a clinical trial and include an intervention with prospective assignment to study conditions, along with outcomes that evaluate effects on biomedical or behavioral endpoints.

Eligibility is broad and includes many types of U.S. organizations and governmental entities. Eligible applicants include state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments, along with public housing authorities and Indian housing authorities. The opportunity is also open to nonprofit organizations, whether they have 501(c)(3) status or not (as long as they are not institutions of higher education in that category), and to for-profit organizations (other than small businesses) as well as small businesses. Beyond these standard categories, the FOA explicitly calls out additional eligible applicant groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility reflects an intent to support diverse research settings and populations, which can be especially important for multi-site trials seeking representative enrollment.

Administratively, the program is offered as an R01 grant mechanism, which is typically used for substantial, investigator-initiated research projects and, in this case, is specifically tailored to the operational and scientific demands of a multi-site clinical trial. The funding activity category is Health, and the CFDA number listed is 93.866. The opportunity record indicates it was created on 2019-06-24, and it lists an original closing date of 2022-09-07 (noting that actual submission windows and reissues can vary over time, so applicants generally need to confirm current status and dates in the active NIH posting). The award ceiling and expected number of awards are not specified in the provided source data, which often means applicants should look to the full FOA and NIH budget guidance for limits, expectations, and any institute-specific budget considerations.

Overall, this FOA is designed for research teams ready to carry out a rigorously designed, multi-site intervention study with clear hypotheses, defined milestones, and strong operational plans, all tied directly to aging-related research priorities under NIA. It is particularly relevant for investigators who already have the scientific rationale and trial infrastructure readiness to move into full implementation and who can demonstrate the leadership, coordination, and site management capacity needed to execute a complex clinical trial across multiple locations.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2019-06-24.
• Applicants must submit their applications by 2022-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 302

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