Opportunity Information: Apply for PAR 25 296
The National Institutes of Health (NIH) is offering a limited-competition funding opportunity called the Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (CCIA), using the UG3/UH3 cooperative agreement mechanism, with clinical trials listed as optional. The core purpose of this program is to speed up translational research by backing projects that are not only innovative on their own, but also designed to be shared, adopted, and sustained across the CTSA Program Consortium and potentially much more broadly. In practical terms, NIH is looking for investigator-initiated ideas that can move the translational science ecosystem forward, helping the research community generate and deliver new treatments faster and more effectively for all people.
This NOFO specifically emphasizes collaborative development and real-world usability. Applicants are expected to create, test or demonstrate, and then actively disseminate new approaches, technologies, resources, or models that improve how translational research is done across diseases and conditions. The focus is less on narrow, single-site solutions and more on innovations that can scale across institutions, become standard practice, and measurably increase research impact. The language in the opportunity highlights not just invention, but implementation and sustainability, meaning NIH wants solutions that will still be useful after the award ends and that others can realistically adopt.
The funding instrument is a cooperative agreement, which typically means NIH will have substantial involvement during the project, such as ongoing coordination, milestone-based oversight, and collaborative engagement to ensure the work stays aligned with program goals. The UG3/UH3 structure generally signals a phased approach: an initial stage oriented toward planning, feasibility work, and early demonstration (UG3), followed by an implementation or expansion stage (UH3) if the project meets predefined milestones. Because clinical trials are optional, applicants may propose either trial or non-trial activities as appropriate to the innovation being developed, as long as the project clearly advances translational science and supports broader dissemination.
Eligibility is limited. The listed eligible applicant type includes public and state-controlled institutions of higher education, and the NOFO indicates there are additional eligibility criteria that applicants must review directly in the full announcement. Importantly, foreign organizations are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. This restriction matters for teams that might otherwise plan to place key project components, data coordination, or operational work outside the United States.
Key administrative details include the opportunity number PAR-25-296 and a closing date of October 19, 2027. The award ceiling is $650,000, indicating a maximum funding level per award under this opportunity (with exact budgeting and allowed costs governed by the NOFO terms and the cooperative agreement structure). The opportunity is categorized as discretionary funding and falls under health-related assistance areas, with multiple CFDA numbers associated with NIH programs (93.121, 93.172, 93.307, 93.313, 93.350, 93.846, 93.855, 93.859, 93.865). Overall, this opportunity is aimed at teams positioned to build broadly useful, high-impact translational science innovations that can be deployed across the CTSA consortium and beyond, rather than one-off tools or locally contained improvements.Apply for PAR 25 296
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.307, 93.313, 93.350, 93.846, 93.855, 93.859, 93.865.
- This funding opportunity was created on 2024-12-11.
- Applicants must submit their applications by 2027-10-19.
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health, Income Security and Social Services
Next opportunity: High-Assay Low-Enriched Uranium (HALEU) Nuclear Fuel Supply Chain Innovative Technology Notice of Funding Opportunity (NOFO)
Previous opportunity: Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 25 296
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 25 296) also looked into and applied for these:
| Funding Opportunity |
|---|
| Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Apply for PAR 25 311 Funding Number: PAR 25 311 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $6,250,000 |
| Early Immune System Development and Ontogeny (R01 Clinical Trial Optional) Apply for PAR 25 362 Funding Number: PAR 25 362 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $400,000 |
| Limited Competition: Advancing the Science of Complementary and Integrative Health Approaches to Improve Maternal Health Outcomes (R01 Clinical Trial Required) Apply for RFA AT 25 002 Funding Number: RFA AT 25 002 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $350,000 |
| HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) Apply for RFA AT 25 003 Funding Number: RFA AT 25 003 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $375,000 |
| Development of Novel or Improved Infertility Technologies (R61/R33 Clinical Trial Optional) Apply for RFA HD 26 001 Funding Number: RFA HD 26 001 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed) Apply for PAR 25 450 Funding Number: PAR 25 450 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 25 296", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.