Opportunity Information: Apply for RFA RM 17 030
The funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" (Funding Opportunity Number RFA-RM-17-030) is a National Institutes of Health (NIH) cooperative agreement designed to push glycoscience forward by making carbohydrate research more practical, approachable, and widely usable across biomedical fields. It sits within the NIH Common Fund effort called "Accelerating Translation of Glycoscience Integration and Accessibility," which is focused on breaking down long-standing technical barriers that have kept many researchers from working with glycans. In plain terms, the program recognizes that carbohydrates and glycans play major roles in biology and disease, but that studying them has often been too specialized, too expensive, or too technically demanding for most labs. The goal of this initiative is to change that by supporting the creation of tools and technologies that are both accessible and affordable, so that researchers who do not consider themselves glycoscientists can still incorporate glycan-related questions into their work.
This opportunity uses the U01 mechanism, meaning it is a cooperative agreement rather than a typical grant. That structure generally indicates substantial involvement or partnership from NIH program staff during the course of the project, with an emphasis on meeting agreed-upon milestones and producing deliverables that are broadly useful to the research community. The focus is not simply on generating knowledge for one narrow use case, but on building enabling platforms, methods, or toolsets that can help many different biomedical researchers identify glycans, track them in biological systems, manipulate them experimentally, and analyze their functions in health and disease settings.
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), through the NIH, and it is listed under CFDA number 93.310, within the health funding activity category. The posting was created on August 4, 2017, with an original closing date of October 27, 2017. The opportunity anticipated making about four awards, with an award ceiling of $320,000. This suggests a targeted, competitive solicitation aimed at a small number of highly promising tool-development projects that could have outsized impact if successfully delivered and adopted by the broader community.
Eligibility is broad and includes many types of organizations, reflecting the program's interest in pulling expertise from academia, government, nonprofit research, and the private sector. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories as specified); for-profit organizations other than small businesses; and small businesses. The listing also notes "others" may be eligible as clarified in the full opportunity text, which typically means additional categories may qualify under specific circumstances.
At its core, the scientific motivation behind the program is that glycans are structurally complex and highly diverse, and they influence a wide range of biological processes, from cell-cell communication and immune recognition to protein stability, pathogen interactions, and signaling pathways. Despite their importance, glycan research has lagged behind areas like genomics and proteomics in terms of standardized, widely available methods and easy-to-use analytical workflows. By investing in novel and innovative tools that facilitate identification, tracking, manipulation, and functional analysis of glycans, the NIH Common Fund aims to help the broader biomedical community integrate glycoscience into mainstream research. The intended outcome is a toolkit ecosystem that lowers the barrier to entry, enables cross-disciplinary studies, and ultimately improves understanding of how glycan structures and glycan-mediated processes contribute to both normal physiology and disease mechanisms.Apply for RFA RM 17 030
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Aug 04, 2017.
- Applicants must submit their applications by Oct 27, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $320,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" and the Funding Opportunity Number is RFA-RM-17-030.
Which agency is sponsoring this funding opportunity?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH).
What NIH initiative is this opportunity associated with?
This opportunity is part of the NIH Common Fund effort called "Accelerating Translation of Glycoscience Integration and Accessibility."
What is the main purpose of this program?
The program is designed to push glycoscience forward by supporting the creation of tools and technologies that make carbohydrate (glycan) research more practical, approachable, affordable, and widely usable across biomedical fields.
Why is NIH emphasizing tool development for glycans?
Glycans play major roles in biology and disease, but studying them has often been too specialized, expensive, or technically demanding for many labs. NIH is aiming to reduce long-standing technical barriers so more researchers can include glycan-related questions in their work.
What does the U01 mechanism mean in this context?
U01 is a cooperative agreement, not a typical grant. This generally means there is substantial involvement or partnership from NIH program staff during the project, with an emphasis on meeting agreed-upon milestones and producing deliverables that are broadly useful to the research community.
What types of projects is this opportunity meant to support?
It supports the development of novel and innovative tools and technologies that help researchers identify glycans, track glycans in biological systems, manipulate glycans experimentally, and analyze glycan functions in health and disease.
Is this funding intended for narrow, single-lab applications?
No. The focus is on building enabling platforms, methods, or toolsets with broad utility, rather than generating knowledge for a single narrow use case.
What outcomes is NIH aiming for?
The intended outcome is a toolkit ecosystem that lowers barriers to entry, enables cross-disciplinary studies, and improves understanding of how glycan structures and glycan-mediated processes contribute to normal physiology and disease mechanisms.
How many awards were anticipated?
The opportunity anticipated making about four awards.
What is the award ceiling?
The award ceiling listed for this opportunity is $320,000.
When was the opportunity posted, and what was the original closing date?
The posting was created on August 4, 2017, and the original closing date was October 27, 2017.
What is the CFDA number associated with this program?
The CFDA number listed is 93.310.
What funding activity category is this listed under?
It is listed under the health funding activity category.
Who is eligible to apply?
Eligibility is broad and includes many organization types across government, academia, nonprofit research, and the private sector.
Which government entities are eligible applicants?
Eligible government applicants include state governments; county governments; city or township governments; and special district governments.
Are tribal entities eligible?
Yes. Federally recognized Native American tribal governments and other tribal organizations are listed as eligible.
Are higher education institutions eligible?
Yes. Public and state-controlled institutions of higher education, as well as private institutions of higher education, are eligible.
Are nonprofits eligible to apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible (with the note that the nonprofit categories exclude higher education institutions as specified in the listing).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also listed as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Does the listing allow any additional eligible applicant categories?
Yes. The listing notes that "others" may be eligible as clarified in the full opportunity text, which typically indicates additional categories may qualify under specific circumstances.
What scientific problem is this program trying to address?
The program is addressing the challenge that glycans are structurally complex and highly diverse, and that glycan research has lagged behind fields like genomics and proteomics due to fewer standardized, widely available methods and user-friendly analytical workflows.
What biological areas make glycans important to study?
Glycans influence many biological processes, including cell-cell communication, immune recognition, protein stability, pathogen interactions, and signaling pathways.
Who is the program trying to help, beyond glycoscience specialists?
A key goal is to make glycan tools accessible to biomedical researchers who do not consider themselves glycoscientists, so they can incorporate glycan-related questions into their own fields.
What kinds of capabilities should the funded tools enable?
Based on the stated scope, tools should facilitate: (1) identification of glycans, (2) tracking of glycans in biological systems, (3) experimental manipulation of glycans, and (4) analysis of glycan functions in health and disease contexts.
What makes this opportunity "targeted" or competitive based on the details provided?
The solicitation anticipated about four awards and listed an award ceiling of $320,000, suggesting a selective program focused on a small number of promising tool-development projects expected to have broad impact if adopted by the wider research community.
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