Opportunity Information: Apply for PA 20 197

The Mentored Quantitative Research Development Award (K25) is a National Institutes of Health (NIH) career development grant meant to bring talented quantitative scientists and engineers into biomedical and behavioral research that is relevant to human health and disease. The main idea is to support investigators who have strong training and accomplishments in quantitative or engineering fields, but whose prior work has not been primarily centered on health and disease questions. Through the K25, NIH provides dedicated, protected time and mentored support so that the awardee can gain the biomedical domain knowledge, research experience, and career momentum needed to transition their quantitative expertise into NIH-relevant research.

This specific Funding Opportunity Announcement (FOA), PA 20-197, is tailored for applicants who will be leading their own independent clinical trial as part of their research and career development plan. That includes serving as the lead investigator for an independent clinical trial, running a clinical trial feasibility study, or conducting a distinct ancillary clinical trial connected to a larger parent trial. In other words, the applicant is expected to be in charge of the clinical trial component rather than simply participating in a trial run by someone else. If a candidate is not planning to lead an independent clinical trial and instead wants experience by working on a clinical trial led by another investigator, NIH directs them to apply to the companion FOA that matches that circumstance.

The award is designed for productive professionals from quantitative disciplines such as mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering. The grant supports a supervised period of study and research under mentorship, with the explicit goal of integrating the candidate’s technical strengths with biomedical or clinical research needs. The expectation is that, by the end of the mentored period, the investigator will be positioned to compete for independent research funding and to sustain a research program that applies quantitative methods to meaningful health and disease problems.

Eligibility for applicant organizations is broad and includes many types of U.S.-based institutions and entities. Eligible applicants listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other organizations. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.

Foreign eligibility is limited in a way that is common for many NIH opportunities. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning certain parts of the proposed work may be conducted in collaboration with foreign sites or resources if they meet NIH’s definition and policy requirements.

Administrative details in the source data show that the opportunity is categorized as a discretionary grant with activity areas spanning education, environment, food and nutrition, health, and social services, and it is associated with multiple CFDA numbers (including 93.113, 93.121, 93.172, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, and 93.866). The issuing agency is the NIH. The record shows an original closing date of 2024-05-07, and the FOA was created on 2020-05-07. The source data does not provide an award ceiling or expected number of awards, so those specifics are not stated here.

Overall, this K25 FOA is best understood as a mentored career on-ramp for quantitative researchers who are ready to pivot into clinical and health-related research by combining their technical background with structured mentorship, protected research time, and a focused plan that includes leadership of an independent clinical trial or closely related trial activity.

  • The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, 93.866.
  • This funding opportunity was created on 2020-05-07.
  • Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PA 20 197

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Funding Number: PA 20 248
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Funding Number: PA 20 251
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Funding Number: PA 20 261
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Funding Number: PA 21 051
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Funding Number: PA 21 052
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