Opportunity Information: Apply for PAR 23 068
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health released this limited competition Funding Opportunity Announcement (FOA) to support a specialized resource project using the R28 grant mechanism, and it is explicitly not intended to support clinical trials. The opportunity is aimed at sustaining and expanding a Brain Tissue Resource Center for Alcohol Research that is already operating under an existing NIAAA-supported grant. In other words, it is not a broad, open call for brand-new centers; it is structured to fund a specific kind of continuation or closely related resource effort led by a currently supported center, with the goal of strengthening national and international research capacity around alcohol-related brain injury and disease.
The core purpose of the project is to build and maintain a high-quality, well-characterized bank of postmortem human brain tissue relevant to alcohol research. That includes collecting and distributing both fresh-frozen tissue and formalin-fixed tissue, and doing so from two key groups: individuals with alcoholism (or alcohol use disorder-related histories) and appropriate control cases. A major emphasis is on ensuring that the tissue bank is not just large, but clinically and pathologically reliable, meaning cases should have confirmed diagnoses based on clinical histories and neuropathological evaluation. This kind of confirmation matters because alcohol-related brain damage can overlap with other neurologic and psychiatric conditions, and research findings are much more useful when the underlying case definitions are solid and consistently applied.
A second major aim is the development and active promotion of a prospective brain donor program in Australia, referred to in the FOA as "Using our Brains." The intention here is to increase both the quantity and quality of donations over time by enrolling donors prospectively, rather than relying only on opportunistic or retrospective tissue acquisition. Prospective donor programs typically allow more complete clinical characterization, better documentation of alcohol exposure and comorbidities, and stronger links between donor histories and postmortem findings, all of which increase the scientific value of the specimens.
The FOA also calls for establishing an associated DNA (blood) bank derived from the brain donor group. This component is meant to complement the brain tissue resource by enabling genetic and genomic research alongside neuropathology, neurobiology, and other tissue-based analyses. Having matched DNA sources can support a wide range of studies, such as evaluating genetic risk factors for alcohol-related neurodegeneration, exploring gene-by-environment interactions, or integrating genomic data with brain-based molecular measures. Building the DNA bank from the same donor cohort strengthens the ability to connect genetic information with detailed phenotypic and neuropathological profiles.
Finally, the resource center is expected to serve as a platform that actively invites and supports outside investigators. The FOA highlights the goal of encouraging research groups with an interest in alcohol-related brain damage to submit applications for studies using the banked tissues. In practical terms, this positions the center as a shared infrastructure: it curates specimens, promotes awareness of the resource, and enables broader scientific use by making well-annotated tissue and related biospecimens available to qualified research teams. This model is designed to accelerate research by reducing barriers to access and improving consistency across studies that depend on human postmortem material.
Administratively, the opportunity is listed as PAR-23-068, a discretionary grant in the health category, associated with CFDA number 93.273. The original closing date shown is March 14, 2023, and the posting indicates it was created on December 27, 2022. The eligibility language indicates it is a limited competition focused on a currently supported center under the named Brain Tissue Resource Center for Alcohol Research award, while also noting that additional eligibility details appear in the full FOA and that small businesses are included among eligible applicants in the provided source data. The key takeaway is that the announcement is tightly targeted: it is meant to maintain and expand a high-value, shared brain and DNA resource for alcohol research, strengthen donor recruitment through a prospective program in Australia, and broaden access for research teams studying alcohol-related harm to the brain, all under a resource-project framework rather than a clinical trial program.Apply for PAR 23 068
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Brain Tissue Resource Center for Alcohol Research (R28 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2022-12-27.
- Applicants must submit their applications by 2023-03-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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