Opportunity Information: Apply for PAR 23 100
The IDeA Networks of Biomedical Research Excellence (INBRE) program is a National Institutes of Health (NIH) grant opportunity administered by the National Institute of General Medical Sciences (NIGMS). It uses the P20 exploratory center-type mechanism and is listed as "Clinical Trial Optional," meaning applicants may propose research that includes clinical trials if it fits the program goals, but a clinical trial is not required. Overall, the program is designed to build and expand long-term biomedical research capacity in states and jurisdictions that are eligible under the Institutional Development Award (IDeA) program, with an emphasis on creating sustainable research infrastructure, strengthening research training and mentorship, and increasing the competitiveness of investigators and institutions for future NIH funding.
At its core, INBRE supports statewide (or jurisdiction-wide) research networks anchored by a lead organization that already has meaningful biomedical research activity and the administrative capability to run a multi-institution program. The lead organization is typically a biomedical research institution that awards doctoral degrees in health sciences or in sciences related to health, or an independent biomedical research institute with ongoing NIH or other federal biomedical research funding. The network model is central to INBRE: it is meant to connect research-intensive institutions with partners such as primarily undergraduate institutions, community colleges, and, where relevant, Tribally Controlled Colleges and Universities (TCCUs). The goal of these partnerships is to broaden participation in biomedical research, create clear pathways for students and early-career investigators, and spread research opportunities and resources across the state rather than concentrating them in a single campus or city.
The program is explicitly about capacity-building in IDeA-eligible states, so proposed activities are expected to strengthen the research environment and talent pipeline. In practical terms, INBRE awards often support shared research resources and core facilities, faculty development and mentoring structures, student research experiences, pilot project programs that help investigators generate preliminary data, and network-wide coordination that makes collaborations easier across institutions. By design, INBRE aims to raise the overall level of biomedical research activity and competitiveness in regions that historically receive a smaller share of NIH funding, while also encouraging meaningful collaboration among institutions with different missions and levels of research intensity.
Eligibility is broad in the sense that many organization types can apply, but the program is still anchored in IDeA eligibility and U.S.-based operations. The opportunity lists eligible applicants that include public and private institutions of higher education, state and local governments, tribal governments (including federally recognized tribes) and certain tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, independent school districts, special district governments, public housing authorities/Indian housing authorities, and other entities. It also highlights a range of institution types that may participate or apply as appropriate, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, TCCUs, and U.S. territories or possessions. However, there are clear restrictions on foreign involvement: non-U.S. (foreign) organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. In short, this is intended to be a domestic, network-based capacity-building program within IDeA jurisdictions.
From an administrative standpoint, this opportunity is a discretionary grant in the health funding category and is associated with CFDA number 93.859. The funding opportunity number is PAR-23-100, and it was created on February 10, 2023. The source information provided lists an original closing date of May 22, 2025. The award ceiling and expected number of awards are not specified in the provided excerpt, which usually means applicants should consult the full funding announcement for budget limits, project period expectations, and any caps by component or by year.
In summary, INBRE (P20) is essentially a statewide biomedical research network-building grant. NIGMS is looking for strong, coordinated proposals that can demonstrate how a lead institution and its partners will work together to expand research infrastructure, support investigators and trainees, and create durable collaborations that lift biomedical research capacity across an IDeA-eligible state or jurisdiction, all within a strictly U.S.-based program structure.Apply for PAR 23 100
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "IDeA Networks of Biomedical Research Excellence (INBRE) (P20 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2023-02-10.
- Applicants must submit their applications by 2025-05-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH NIGMS INBRE (P20) Grant Opportunity (PAR-23-100)
What is the INBRE program?
The IDeA Networks of Biomedical Research Excellence (INBRE) program is a National Institutes of Health (NIH) funding opportunity administered by the National Institute of General Medical Sciences (NIGMS). It uses the P20 exploratory center-type mechanism and is designed to build and expand long-term biomedical research capacity in IDeA-eligible states and jurisdictions.
What does INBRE funding support, in general terms?
INBRE is focused on capacity-building through statewide (or jurisdiction-wide) research networks. Supported activities commonly include developing sustainable research infrastructure, strengthening research training and mentorship, supporting faculty development, providing student research experiences, running pilot project programs to generate preliminary data, building/maintaining shared research resources and core facilities, and coordinating network-wide collaboration across institutions.
What is the main goal of INBRE?
The main goal is to raise and sustain biomedical research capacity and competitiveness in regions that historically receive a smaller share of NIH funding. INBRE aims to improve research infrastructure, strengthen the talent pipeline, and increase the competitiveness of investigators and institutions for future NIH funding.
Who administers this grant program?
This opportunity is administered by NIH through NIGMS (the National Institute of General Medical Sciences).
What funding mechanism does INBRE use?
INBRE uses the P20 exploratory center-type mechanism.
Is a clinical trial required for this opportunity?
No. The opportunity is listed as "Clinical Trial Optional." That means an applicant may propose research that includes clinical trials if it fits the program goals, but clinical trials are not required.
What is the network model in INBRE?
INBRE is built around a statewide (or jurisdiction-wide) network anchored by a lead organization. The network is meant to connect research-intensive institutions with partner institutions such as primarily undergraduate institutions, community colleges, and (where relevant) Tribally Controlled Colleges and Universities (TCCUs), to broaden participation and distribute research opportunities across the state or jurisdiction.
What is expected of the lead organization?
The lead organization is expected to have meaningful biomedical research activity and the administrative capability to run a multi-institution program. The lead is typically a biomedical research institution that awards doctoral degrees in health sciences (or sciences related to health) or an independent biomedical research institute with ongoing NIH or other federal biomedical research funding.
Why does the program emphasize partnerships across different kinds of institutions?
The partnerships are intended to broaden participation in biomedical research, create clearer pathways for students and early-career investigators, and spread research opportunities and resources across the state or jurisdiction rather than concentrating them in one campus or city.
Is this grant limited to a single institution?
No. The program is designed around a network approach, meaning it supports coordinated, multi-institution collaborations across a state or jurisdiction, anchored by a lead organization.
Which states or jurisdictions are the focus of INBRE?
INBRE is intended for states and jurisdictions eligible under the Institutional Development Award (IDeA) program. Proposed activities are expected to build capacity within those IDeA-eligible regions.
What kinds of organizations are eligible to apply?
The opportunity lists a wide range of eligible applicant types, including public and private institutions of higher education, state and local governments, tribal governments (including federally recognized tribes) and certain tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, independent school districts, special district governments, public housing authorities/Indian housing authorities, and other entities.
Are minority-serving institutions or community-based organizations included in the eligible landscape?
The opportunity highlights that a range of institution types may participate or apply as appropriate, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-U.S. (foreign) organizations are not eligible to apply under this opportunity.
Can a U.S. organization include a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
Is this opportunity considered a domestic program?
Yes. Based on the stated eligibility restrictions, the program is intended to be a strictly U.S.-based, network-driven capacity-building effort within IDeA jurisdictions.
What is the funding opportunity number?
The funding opportunity number is PAR-23-100.
When was this opportunity created?
The opportunity was created on February 10, 2023.
What is the listed closing date in the provided information?
The source information provided lists an original closing date of May 22, 2025.
Is the award ceiling provided in the excerpt?
No. The award ceiling is not specified in the provided excerpt.
Is the expected number of awards provided in the excerpt?
No. The expected number of awards is not specified in the provided excerpt.
What should applicants do if they need budget limits or project period details?
Because the excerpt does not include award ceilings, expected number of awards, or detailed budget limits, applicants should consult the full funding announcement for budget guidance, project period expectations, and any caps by component or by year.
How is this opportunity categorized in terms of funding type and topic?
It is described as a discretionary grant in the health funding category.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.859.
What makes an INBRE proposal strong based on the description provided?
Based on the description, strong proposals are likely to be well-coordinated statewide (or jurisdiction-wide) network plans that show how a capable lead institution and partners will work together to expand research infrastructure, strengthen mentorship and training, support investigators and trainees, enable collaboration across institutions, and create durable, sustainable improvements in biomedical research capacity within an IDeA-eligible region.
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